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Deferoxamine - FDA prescribing information, side effects …
- https://www.drugs.com/pro/deferoxamine.html
- Deferoxamine mesylate for injection, USP, is an iron-chelating agent, available in vials for intramuscular, subcutaneous, and intravenous administration. Deferoxamine mesylate is supplied as vials containing 500 mg and 2 g of Deferoxamine mesylate USP in sterile, lyophilized form. Deferoxamine mesylate is N-[5-[3-[(5-aminopentyl)hy…
Deferoxamine - an overview | ScienceDirect Topics
- https://www.sciencedirect.com/topics/medicine-and-dentistry/deferoxamine
- James R. Roberts MD, FACEP, FAAEM, FACMT, in Roberts and Hedges’ Clinical Procedures in Emergency Medicine and Acute Care, 2019 Deferoxamine. Deferoxamine is an organic compound derived from the bacterium Streptomyces pilosus and can chelate iron. It can be used as a therapy or as a diagnostic challenge in patients with iron overdoses. Patients who have …
Deferoxamine Monograph for Professionals - Drugs.com
- https://www.drugs.com/monograph/deferoxamine.html
- none
Deferoxamine - LiverTox - NCBI Bookshelf
- https://www.ncbi.nlm.nih.gov/books/NBK547998/
- Deferoxamine (de” fer ox’ a meen) is parenterally administered iron chelating agent that binds iron with a high affinity and zinc and copper to a lesser extent. In clinical trials in patients with transfusion related iron overload, deferoxamine therapy lowered both circulating and tissue (cardiac, liver) iron levels and these reductions ...
Overview of iron chelation therapy with desferrioxamine …
- https://pubmed.ncbi.nlm.nih.gov/20001633/
- Abstract. Chronic iron overload from frequent blood transfusions to treat patients with severe anemias leads to significant morbidity and mortality. Although desferrioxamine, the current standard of care, is an effective iron chelator with long-term evidence, it requires tedious subcutaneous infusion that reflects negatively on patient compliance.
Iron Chelation Adherence to Deferoxamine and …
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599708/
- For decades, the standard iron chelation therapy in thalassemia was deferoxamine (Desferal ®, DFO), a subcutaneous or intravenous infusion, typically 8–12 hr per day, 5–7 days per week, and associated with poor adherence in some patients.Adherence is essential to decrease the risk of complications and mortality due to iron overload in transfused thalassemia patients.
Thalassemia.com: Standard of Care Guidelines
- https://www.thalassemia.com/treatment-chelation-desferal.aspx
- Subcutaneous deferoxamine should be administered at 30 to 60 mg/kg for eight to fifteen hours, five to seven days or nights per week. Deferoxamine should run over a minimum of six hours (or longer) at a maximum of 15 mg/kg per hour. High doses of deferoxamine—more than 4 to 6 grams over 24 hours—should not be given.
Pattern dystrophies in patients treated with …
- https://bmcophthalmol.biomedcentral.com/articles/10.1186/s12886-018-0911-2
- Adult onsel vitelliform macular dystrophy in a 54 year old patient (Patient 1) receiving deferoxamine chelation therapy for transfusional iron overload due to beta thalassemia intermedia. Fundus photography demonstrates the yellowish lesions with central and parafoveal hyperpigmentation in both maculas as well as angioid streaks arising from both optic discs ( a , …
Desferal (deferoxamine mesylate) for injection
- https://www.accessdata.fda.gov/drugsatfda_docs/label/2007/016267s044lbl.pdf
- Desferal ® deferoxamine mesylate for injection USP ... As an adjuvant to iron chelation therapy, vitamin C in doses up to 200 mg for adults may be given in divided doses, starting after an initial month of regular treatment with Desferal (see PRECAUTIONS). Vitamin C increases availability of iron for chelation. In general, 50 mg daily suffices ...
Thalassemia.com: Standard of Care Guidelines - Chelation, …
- https://www.thalassemia.com/treatment-chelation-desferal-guide-intro.aspx
- An expected acute reaction with a sub-Q injection is a localized erythematous rash. Hydrocortisone can be mixed with Desferal to decrease this reaction. A common occurrence is irritation at the site of administration. This can be decreased by diluting the Desferal. Over-chelation will cause growth disturbance and mineral deficiency.
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